RT Journal
A1 Koenen KC, Galea S
T1 GEne-environment interactions and depression
JF JAMA
JO JAMA
YR 2009
FD November 4
VO 302
IS 17
SP 1859
OP 1862
DO 10.1001/jama.2009.1575
UL http://dx.doi.org/10.1001/jama.2009.1575
AB 
To the Editor: In their meta-analysis, Dr Risch and colleagues1 concluded that the study of gene-environment interaction in mental disorders should await the identification of “robust marginal gene associations.” We believe that this conclusion extends well beyond the data, and an alternate explanation of their findings suggests other courses of action. The absence of replicable findings across studies that assessed both direct genotype-depression associations and gene-environment interactions may be explained by mismeasurement and undermeasurement of relevant environmental contexts.