RT Journal A1 Quinet RJ T1 RHeumatoid arthritis JF JAMA JO JAMA YR 2009 FD November 4 VO 302 IS 17 SP 1909 OP 1914 DO 10.1001/jama.2009.1597 UL http://dx.doi.org/10.1001/jama.2009.1597 AB One example is the excellent chapter by Zink explaining the details of the various European Biologics Registries, which is contrasted with the chapter by Kremer on the US approach to registries and databases. These chapters can serve as references to help interpret future clinical data forthcoming from these registries. Such registry data are critical to advancing knowledge regarding long-term complications of biologic therapies, particularly malignancies and infections. The section on epidemiology provides an excellent, readable chapter on the latest genetic studies, placing them in historical perspective and, for example, relating new genetic detail regarding the MHC-region HLA- DRĪ²1, its interaction with environmental factors (eg, tobacco), and induction of anti-citrullinated protein antibody formation.