RT Journal A1 Keirns CC, Goold S T1 PAtient-centered care and preference-sensitive decision making JF JAMA JO JAMA YR 2009 FD October 28 VO 302 IS 16 SP 1805 OP 1806 DO 10.1001/jama.2009.1550 UL http://dx.doi.org/10.1001/jama.2009.1550 AB In most situations, patients value prevention of disease and disability and increased length of life, so patient-centered care and application of evidence-based medicine present no conflict. Despite general preferences for health over disease, however, individuals make trade-offs every day by working in dangerous or stressful jobs, driving too fast, eating too much, smoking, and taking dozens of other risks, large and small. These everyday compromises are also seen in clinical practice. Patients may choose a less expensive medication even if that medication is not quite as effective. They may choose a more limited operation for cancer, explicitly trading off survival for quality of life. They may decline chemotherapy because they feel the adverse effects are not worth the small chance of success.