RT Journal
A1 Wise MP, Saayman AG, Frost PJ
T1 ACid-suppressive medication and hospital-acquired pneumonia
JF JAMA
JO JAMA
YR 2009
FD October 7
VO 302
IS 13
SP 1415
OP 1417
DO 10.1001/jama.2009.1415
UL http://dx.doi.org/10.1001/jama.2009.1415
AB 
To the Editor: Acid suppression therapy is associated with an increased risk of community-acquired pneumonia, and Dr Herzig and colleagues1 reported that these drugs also increase the odds of HAP by 30%. Unlike community-acquired pneumonia, this association was only apparent with proton-pump inhibitors, although it was acknowledged that the study might have been underpowered to detect a smaller effect with histamine2 receptor antagonists. Two mechanisms were suggested for the increase in pneumonia: gastric overgrowth and aspiration of bacteria, and impaired leukocyte function.