RT Journal A1 Stephenson J T1 PRedicting joint replacement JF JAMA JO JAMA YR 2009 FD September 16 VO 302 IS 11 SP 1161 OP 1161 DO 10.1001/jama.2009.1338 UL http://dx.doi.org/10.1001/jama.2009.1338 AB The prospective cohort study involved more than 900 randomly selected residents of Bruneck, Italy, in their 40s, 50s, 60s, and 70s. Demographic characteristics, lifestyle factors, and biochemical variables, including the level of VCAM-1 in the blood, were assessed at a baseline visit in 1990. Over the next 15 years, 60 participants had hip or knee joint replacement surgery.