RT Journal
A1 Weissman MM, Talati A
T1 DEpression in at-risk adolescents and their parents
JF JAMA
JO JAMA
YR 2009
FD September 16
VO 302
IS 11
SP 1167
OP 1168
DO 10.1001/jama.2009.1329
UL http://dx.doi.org/10.1001/jama.2009.1329
AB 
An ancillary study of children of parents receiving treatment as part of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) found that remission of maternal depression after 3 months of medication was significantly associated with reductions in the children's diagnoses and symptoms.2 Conversely, a failure to remit was associated with worsening in child outcomes, paralleling observations by Garber et al that cognitive behavioral therapy did not confer a protective effect among the offspring of currently depressed parents. The STAR*D findings were sustained in offspring of mothers who remitted later after the first 3 months of treatment3 and were supported by consistent findings in an independent randomized controlled trial covering 9 months and using another evidence-based psychotherapy for the depressed mothers.4