RT Journal
A1 Kuehn BM
T1 NEw inflammatory disorder
JF JAMA
JO JAMA
YR 2009
FD July 22
VO 302
IS 4
SP 375
OP 375
DO 10.1001/jama.2009.1049
UL http://dx.doi.org/10.1001/jama.2009.1049
AB 
The protein product of IL1RN inhibits IL-1, and unchecked IL-1 causes life-threatening inflammation in these patients, according to the scientists. Five of 6 surviving patients treated with anakinra, a recombinant IL-1–receptor antagonist, experienced remission; the patient who did not respond to the drug had chromosomal deletions that included IL1RN, the authors report.