RT Journal A1 Norris SL T1 CLinical practice guidelines and scientific evidence JF JAMA JO JAMA YR 2009 FD July 8 VO 302 IS 2 SP 142 OP 147 DO 10.1001/jama.2009.908 UL http://dx.doi.org/10.1001/jama.2009.908 AB To the Editor: Dr Tricoci and colleagues1 published an analysis indicating that American College of Cardiology/American Heart Association (ACC/AHA) guidelines are largely developed from lower levels of evidence or expert opinion. They concluded that there is a “need to improve the process of writing guidelines and to expand the evidence base from which clinical practice guidelines are derived.” Their first conclusion could have been better substantiated by a critical appraisal of the ACC/AHA guideline methods.2