RT Journal A1 Stephenson J T1 EXercise and antioxidants JF JAMA JO JAMA YR 2009 FD June 17 VO 301 IS 23 SP 2432 OP 2432 DO 10.1001/jama.2009.820 UL http://dx.doi.org/10.1001/jama.2009.820 AB Exercise improves sensitivity to insulin. But when muscle cells metabolize glucose, “free radicals”—reactive oxygen species (ROS), which can cause cell damage—are produced. However, the researchers reasoned, because reduced mitochondrial metabolism has been linked with type 2 diabetes, ROS generated by exercise also may have a health-promoting effect that antioxidants such as vitamin C or E might undermine.