RT Journal
A1 Dervaux A, Laqueille X
T1 ANtidepressant treatment and smoking cessation in bipolar disorder
JF JAMA
JO JAMA
YR 2009
FD May 27
VO 301
IS 20
SP 2093
OP 2093
DO 10.1001/jama.2009.705
UL http://dx.doi.org/10.1001/jama.2009.705
AB 
Bupropion, used to reduce tobacco smoking, is also widely used as an antidepressant. In a 26-week double-blind, placebo-controlled study in patients with bipolar depression,2 the use of standard antidepressant medication (including bupropion) as adjuncts to mood stabilizers was not associated with increased efficacy compared with the use of mood stabilizers alone; in addition, there was no increased risk of treatment-emergent affective switch. In randomized trials of bupropion, sertraline, or venlafaxine as an adjunct to a mood stabilizer,3 acute antidepressant augmentation was associated with a modest response rate; the rate of mania precipitation associated with bupropion use was 6.1% in the acute treatment trials and 12.5% in continuation trials lasting up to 1 year.4 However, bupropion was associated with a lower risk of such activation compared with venlafaxine.4