RT Journal
A1 Nyirenda MJ, Beckett GJ, Toft AD
T1 CArbimazole treatment in smokers vs nonsmokers with graves disease—reply
JF JAMA
JO JAMA
YR 2009
FD May 20
VO 301
IS 19
SP 1988
OP 1989
DO 10.1001/jama.2009.557
UL http://dx.doi.org/10.1001/jama.2009.557
AB 
However, these relationships have not been adequately studied and are likely to be more complex. In particular, it is unclear whether the association between Graves disease and circulating soluble IL-2 receptor concentration reflects the underlying autoimmune activity or, as some studies have suggested, is mediated by the hyperthyroidism. In the latter case, hyperthyroidism of any cause would elevate soluble IL-2 receptor concentration while hypothyroidism would have the opposite effect.1- 3 We agree that further research is needed to fully address these unanswered questions.