RT Journal A1 Friedman AH T1 TAmsulosin and the intraoperative floppy iris syndrome JF JAMA JO JAMA YR 2009 FD May 20 VO 301 IS 19 SP 2044 OP 2045 DO 10.1001/jama.2009.704 UL http://dx.doi.org/10.1001/jama.2009.704 AB The intraoperative floppy iris syndrome (IFIS) was first described by Chang and Campbell in 2005.1 These authors1 and others2 observed that there was a tendency for poor pupillary dilation and the intraoperative triad of the billowing of a flaccid iris, the propensity for iris prolapse, and progressive intraoperative pupillary constriction. In the current technique ophthalmologists perform cataract surgery through a 2.5-mm incision. A widely dilated pupil is essential for complication-free surgery. Billowing of the iris into the surgical field and poor pupillary constriction are potentially catastrophic barriers to successful surgery. Intraoperative floppy iris syndrome is encountered mainly in cataract surgery and in prospective studies has been found to occur in 2% to 3% of all cataract operations and to a lesser extent in glaucoma surgery.3