RT Journal A1 Reiffel JA T1 EQuivalence of generic and brand-name drugs for cardiovascular disease JF JAMA JO JAMA YR 2009 FD April 22 VO 301 IS 16 SP 1654 OP 1656 DO 10.1001/jama.2009.522 UL http://dx.doi.org/10.1001/jama.2009.522 AB To the Editor: Although the observations of Dr Kesselheim and colleagues1 are generally accurate, the authors oversimplified the issue and did not adequately consider all of the evidence. They largely grouped the material they reviewed into clinical trials and editorials. The former were appropriately given more weight in the authors' conclusions. However, case report material in some editorials as well as in articles that were not included2 (such as reports of serious arrhythmic recurrences, proarrhythmic events, and deaths in association with formulation substitution of an antiarrhythmic drug) was ignored.