RT Journal A1 Chellappa P, Ramaraj R T1 DEpression, homocysteine concentration, and cardiovascular events JF JAMA JO JAMA YR 2009 FD April 15 VO 301 IS 15 SP 1541 OP 1542 DO 10.1001/jama.2009.490 UL http://dx.doi.org/10.1001/jama.2009.490 AB The observational Health in Men Study2 suggested an association between depression and high homocysteine concentration. Other studies have shown an association of depression with B12 and folate deficiency.2- 3 Homocysteine level is a marker of deficiency of B12 and folate, and patients with depression have increased levels of homocysteine.2