RT Journal
A1 Stephenson J
T1 FIghting the flu
JF JAMA
JO JAMA
YR 2009
FD April 1
VO 301
IS 13
SP 1329
OP 1329
DO 10.1001/jama.2009.431
UL http://dx.doi.org/10.1001/jama.2009.431
AB 
The researchers screened a library of human antibodies against hemagglutinin, a protein on the viral surface that enables flu virus to attach to and enter target cells. They identified 3 antibodies that were active against H5N1 avian influenza viruses as well as seasonal H1N1 flu viruses and the strain that caused the 1918 influenza pandemic. X-ray crystallography of one of the antibodies bound to the H5N1 hemagglutinin revealed that part of the antibody was jammed into a pocket on the stem of the virus, preventing the viral shape-shifting needed for the virus to fuse its membrane with the host cell membrane.