RT Journal A1 Mitka M T1 LIfestyle modification and heart disease JF JAMA JO JAMA YR 2009 FD January 14 VO 301 IS 2 SP 150 OP 151 DO 10.1001/jama.2008.916 UL http://dx.doi.org/10.1001/jama.2008.916 AB One of these studies, a randomized controlled trial called FIT Heart (a Family-Based Intervention Trial to Improve Heart Health), enrolled 501 healthy adult family members (66% of whom were female and 36% were nonwhite, with a mean age of 48 years) to test the hypothesis that the hospitalization of a family member with cardiovascular disease could provide a “teachable moment” for motivating adult family members to adopt lifestyle changes that would lower their LDL-C level. These family members were screened for cardiovascular risk factors and counseled about lifestyle changes (consuming a healthier diet and engaging in exercise), and their physicians received progress reports. However, at 1-year follow-up, participants in both the experimental group and the control group (who received only a brief prevention message and a letter to their health care clinician only if they had a critical risk factor for the levels reported) had comparable decreases in LDL-C levels, about 4.4 mg/dL from a mean baseline of about 129.5 mg/dL (Mosca L et al. Circ Cardiovasc Qual Outcomes. 2008;1[2]98-106).