RT Journal A1 Chan E T1 INtegrity of active components of botanical products used in complementary and alternative medicine—reply JF JAMA JO JAMA YR 2008 FD November 5 VO 300 IS 17 SP 1995 OP 1996 DO 10.1001/jama.2008.559 UL http://dx.doi.org/10.1001/jama.2008.559 AB Although these processes add further complexity and cost to studies, the value of rigorous CAM research lies not only in producing scientifically valid and reproducible results but also in establishing an evidence base for appropriate use, dosage, and interactions with other biologically active products (including medications). Consumers of CAM, however, should be aware that commercially available botanicals and dietary supplements are neither subject to such scrutiny nor held to the same Food and Drug Administration regulatory standards as drugs.1- 2