RT Journal
A1 Stamler J, Neaton JD
T1 THe multiple risk factor intervention trial (mrfit)—importance then and now
JF JAMA
JO JAMA
YR 2008
FD September 17
VO 300
IS 11
SP 1343
OP 1345
DO 10.1001/jama.300.11.1343
UL http://dx.doi.org/10.1001/jama.300.11.1343
AB 
In 1986 in JAMA, we reported findings of the 6-year follow-up of the large cohort screened for the Multiple Risk Factor Intervention Trial (MRFIT).1 The article, challenging existing dogmas about the relationship between cholesterol and coronary heart disease (CHD), generated much interest. Now, the 25-year results are available with almost 7% (23 382) of the men deceased due to CHD.2- 4 The 1986 findings and conclusions regarding the relationship of a single measurement of serum cholesterol to premature CHD mortality are verified in depth by the 25-year data with extraordinary precision due to large size of the cohort, long follow-up, and a large number of CHD deaths.