RT Journal
A1 Padayatty SJ, Levine M
T1 STandard-dose vs high-dose multivitamin supplements for hiv
JF JAMA
JO JAMA
YR 2013
FD February 13
VO 309
IS 6
SP 545
OP 546
DO 10.1001/jama.2012.216991
UL http://dx.doi.org/10.1001/jama.2012.216991
AB 
Higher doses of vitamins should result in higher plasma or tissue vitamin concentrations. For vitamin C, the dose-concentration relationship in healthy young women is sigmoidal.2 Rapid increases in plasma concentrations occur at intakes of 30 mg/d to 100 mg/d, with only small increases at higher intakes. For the doses of 80 mg/d (standard-dose regimen) and 500 mg/d (high-dose regimen) of vitamin C used in this study, predicted plasma vitamin C concentrations are 55 μM and 74 μM, respectively, using published dose-concentration curves.2