RT Journal A1 Elbers P, Gatz R, Anstey C T1 CHloride-restrictive fluid administration and incidence of acute kidney injury JF JAMA JO JAMA YR 2013 FD February 13 VO 309 IS 6 SP 542 OP 543 DO 10.1001/jama.2012.171511 UL http://dx.doi.org/10.1001/jama.2012.171511 AB An important point raised by the authors is that their study examined a bundle of care. Therefore, it is plausible that a different component of the bundle was responsible for the observed association. One alternative explanation for the results may have been the more physiological strong ion difference (SID) in the chloride-restrictive group.