RT Journal A1 Albert RK T1 CHloride-restrictive fluid administration and incidence of acute kidney injury JF JAMA JO JAMA YR 2013 FD February 13 VO 309 IS 6 SP 542 OP 542 DO 10.1001/jama.2012.171505 UL http://dx.doi.org/10.1001/jama.2012.171505 AB To the Editor: Dr Yunos and colleagues1 reported that, compared with chloride-liberal intravenous fluid administration, chloride-restrictive fluid administration was associated with a decrease in the incidence of acute kidney injury and the need for renal replacement therapy. When evaluating the association of any intervention with renal function, potential differences in volume administered must be considered. It is difficult to compare the volume of fluid administered when colloid is given as opposed to crystalloid, but it is possible to compare the amount of sodium administered as a surrogate for volume.