RT Journal A1 Inouye SK, O’Connell JJ, Puelle MR T1 FAlling off the edge JF JAMA JO JAMA YR 2013 FD February 6 VO 309 IS 5 SP 451 OP 452 DO 10.1001/jama.2012.214089 UL http://dx.doi.org/10.1001/jama.2012.214089 AB One evening as I (S.K.I.) was clearing the tables in the soup kitchen where I was volunteering, I struck up a conversation with a homeless man. With his long white beard, stooped posture, and limping gait, I was sure he was older than 70 years. I was surprised to learn he was only 48. As a geriatrician with more than 25 years of clinical experience, I am usually pretty good at telling how old someone is. But after this scenario repeated itself several times, I began to wonder whether chronic homelessness might be associated with accelerated aging. Could exposure to the elements and the constant stress of the relentless daily struggle to survive lead to more rapid aging, along with its attendant functional and cognitive decline?