RT Journal
A1 Rutten FH, Groenwold RH
T1 Β-blocker use for patients with or at risk for coronary artery disease
JF JAMA
JO JAMA
YR 2013
FD February 6
VO 309
IS 5
SP 438
OP 438
DO 10.1001/jama.2012.128865
UL http://dx.doi.org/10.1001/jama.2012.128865
AB 
To the Editor: Dr Bangalore and colleagues1 reported that the use of β-blockers was not associated with a lower risk of composite cardiovascular events in patients with coronary artery disease (CAD) risk factors only, known prior myocardial infarction (MI), or known CAD without MI. We agree that the effectiveness of a drug may be altered when diagnosis and treatment advance over time. For example, today CAD less often leads to necrotic and scarred myocardium than decades ago.1 However, we have concerns about this study.