RT Journal
A1 Hampton T
T1 ATopic dermatitis clues
JF JAMA
JO JAMA
YR 2013
FD February 6
VO 309
IS 5
SP 431
OP 431
DO 10.1001/jama.2013.268
UL http://dx.doi.org/10.1001/jama.2013.268
AB 
Investigators at Oregon State University previously found that atopic dermatitis can be triggered by inadequate amounts of a master regulator that controls lipid biosynthesis in the skin— a protein called chicken ovalbumin upstream promoter transcription factor interacting protein 2, or Ctip2 (Ganguli-Indra G et al. Exp Dermatol. 2009;18[11]:994-996). In the group's latest study, they discovered that Ctip2 suppresses thymic stromal lymphopoietin (TSLP), a cytokine that is produced by skin cells and can trigger inflammation. Levels of this inflammatory TSLP were 1000 times higher in laboratory animals that had been genetically modified to express no Ctip2 in their skin.