RT Journal
A1 Hampton T
T1 HIgh-cholesterol pigs
JF JAMA
JO JAMA
YR 2013
FD February 6
VO 309
IS 5
SP 431
OP 431
DO 10.1001/jama.2013.54
UL http://dx.doi.org/10.1001/jama.2013.54
AB 
The researchers inserted a mutated form of the gene that encodes proprotein convertase subtilisin kexin type 9 (PCSK9) into Yucatan minipigs. Humans with mutated PCSK9 develop severe hypercholesterolemia and early atherosclerotic vascular disease.