RT Journal
A1 Hampton T
T1 REstoring the blood-brain barrier
JF JAMA
JO JAMA
YR 2013
FD February 6
VO 309
IS 5
SP 431
OP 431
DO 10.1001/jama.2013.267
UL http://dx.doi.org/10.1001/jama.2013.267
AB 
The investigators also found a significant reduction in circulating ANXA1 in the plasma of patients with multiple sclerosis and a loss of the protein in the cerebral microvasculature of patients who died with the disease. Exposing in vitro cerebrovascular endothelial cells to recombinant ANXA1 restored cellular features (such as cytoskeleton integrity) needed to reinstate the integrity of the blood-brain barrier. Also, giving ANXA1 to mice that lacked the protein decreased leakage through the blood-brain barrier.