RT Journal A1 Whittle SL, Richards BL, Buchbinder R T1 OPioid analgesics for rheumatoid arthritis pain JF JAMA JO JAMA YR 2013 FD February 6 VO 309 IS 5 SP 485 OP 486 DO 10.1001/jama.2012.193412 UL http://dx.doi.org/10.1001/jama.2012.193412 AB Clinical Question  Do the benefits of opioid analgesics outweigh the risks in patients with persistent pain due to rheumatoid arthritis?Bottom Line  Weak opioids (such as codeine, dextropropoxyphene, and tramadol) may be effective in the short-term management of rheumatoid arthritis pain, but adverse effects are common and may outweigh the benefits; alternative analgesics should be considered first.