RT Journal
A1 Prasad V, Jena AB
T1 Prespecified falsification end points: Can they validate true observational associations?
JF JAMA
JO JAMA
YR 2013
FD January 16
VO 309
IS 3
SP 241
OP 242
DO 10.1001/jama.2012.96867
UL http://dx.doi.org/10.1001/jama.2012.96867
AB 
As observational studies have increased in number—fueled by a boom in electronic recordkeeping and the ease with which observational analyses of large databases can be performed—so too have failures to confirm initial research findings.1 Several solutions to the problem of incorrect observational results have been suggested,1- 2 emphasizing the importance of a record not only of significant findings but of all analyses conducted.2