RT Journal
A1 Johnson NP, Kirkeeide RL, Gould K
T1 NOninvasive approach to assess coronary artery stenoses and ischemia
JF JAMA
JO JAMA
YR 2013
FD January 16
VO 309
IS 3
SP 233
OP 236
DO 10.1001/jama.2012.157189
UL http://dx.doi.org/10.1001/jama.2012.157189
AB 
A large scatter between FFR and FFRCT most likely existed in the DeFACTO study,1 although it was not explicit in the article, leaving readers to infer its existence from the tables comparing dichotomized FFR and FFRCT. At best, the paired plot of FFR and FFRCT would mirror the results of the Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve (DISCOVER-FLOW) trial,2 which showed wide limits of agreement between FFRCT and FFR of ±0.13 in addition to a slight bias of −0.02 (underestimation by FFRCT) and correlation of 0.72. The discordance may be even larger in the DeFACTO study because per-patient accuracy (73% vs 87%) and specificity (54% vs 82%) were lower than in the DISCOVER-FLOW study.