RT Journal
A1 Sterk PJ, Sont JK
T1 STrategies for tailoring asthma treatment in adults
JF JAMA
JO JAMA
YR 2013
FD January 9
VO 309
IS 2
SP 135
OP 136
DO 10.1001/jama.2012.73379
UL http://dx.doi.org/10.1001/jama.2012.73379
AB 
The BASALT trial is an example of an asthma treatment algorithm study.2 These kind of studies aim to improve clinical outcome by tailoring treatment with existing drugs based on predefined levels of a quantitative disease marker. The design of such trials is pivotal, including choices regarding the patient population, definition of the clinical end point, clinical room for improvement, selection of the disease marker, discrete levels of the marker leading to treatment changes, and dose adjustments of the drug.3