RT Journal
A1 Anand KS
T1 PAin panacea for opiophobia in infants?
JF JAMA
JO JAMA
YR 2013
FD January 9
VO 309
IS 2
SP 183
OP 184
DO 10.1001/jama.2012.208359
UL http://dx.doi.org/10.1001/jama.2012.208359
AB 
Intravenous acetaminophen (paracetamol) is suggested for use as an opioid-sparing analgesic for children requiring surgery1 or emergency care,2 despite limited data on its efficacy and toxicity in infants and children. In this issue of JAMA, the randomized trial by Ceelie and colleagues3 addresses this evidence gap by showing clinically significant reductions in morphine use among neonates or infants receiving postoperative analgesia. Among patients randomized to receive acetaminophen (n = 33) or morphine (n = 38) postoperatively, the cumulative morphine dose during the first 48 hours following surgery was 121 μg/kg (interquartile range, 99-264) vs 357 μg/kg (interquartile range, 220-605), respectively—a 66% relative reduction between groups (P < .001). There were no differences in the number of patients requiring morphine rescue doses or in pain scores.