RT Journal A1 Punnoose AR, Lynm C, Golub RM T1 SEvere combined immunodeficiency JF JAMA JO JAMA YR 2013 FD January 2 VO 309 IS 1 SP 98 OP 98 DO 10.1001/jama.2012.6226 UL http://dx.doi.org/10.1001/jama.2012.6226 AB Severe combined immunodeficiency (SCID ) results from genetic mutations (changes in genetic material that can be passed on to children) that result in very small numbers of T cells or B cells (types of cells required for a normally functioning immune system). Because mutations in any 1 of at least 13 different genes can lead to SCID, there are several genetic types of SCID. The most common form is X-linked, which means that the gene is passed from mothers to their sons.