RT Journal
A1 Rizos EC, Ntzani EE, Elisaf MS
T1 OMega-3 fatty acid supplementation and cardiovascular disease events—reply
JF JAMA
JO JAMA
YR 2013
FD January 2
VO 309
IS 1
SP 27
OP 27
DO 10.1001/jama.2012.116657
UL http://dx.doi.org/10.1001/jama.2012.116657
AB 
In Reply: Mr Lewis suggests that the dietary or supplemental intake and the source of omega-3 PUFAs are 2 factors that may not have been adequately addressed in our study. We included studies with different omega-3 doses and various proportions of EPA and DHA and performed a meta-regression analysis that did not show a statistically significant association between the cardiovascular outcomes and omega-3 dose. Two studies with intakes of more than 3 g per day and relative risks for all-cause mortality of less than 1.0 had small sample sizes, whereas the third showed a relative risk of 1.0. Regarding the source of omega-3 PUFAs, we included studies without making a distinction about the specific origin because none of the studies provided such information.