RT Journal
A1 Galli C, Brenna J
T1 OMega-3 fatty acid supplementation and cardiovascular disease events
JF JAMA
JO JAMA
YR 2013
FD January 2
VO 309
IS 1
SP 27
OP 27
DO 10.1001/jama.2012.116648
UL http://dx.doi.org/10.1001/jama.2012.116648
AB 
Meta-analysis is best applied to treatment with manufactured drugs of well-defined composition indicated for particular pathological effects. In contrast to drugs, omega-3 PUFAs are obligatory nutrients, being constituents of normally functioning, highly specialized cells (myocardium, neurons, red blood cells) in which they play key structural and signaling roles. Their intake throughout life, mainly through diet, is required in amounts influenced by individual factors such as genotype and physiological conditions. Unlike drugs, long-chain PUFA supplements are variable in their content of active ingredients (eg, EPA and DHA) and excipients, which can lead to heterogeneous effects. Therefore, studies should not ignore initial omega-3 status.