RT Journal A1 Lewis EH T1 OMega-3 fatty acid supplementation and cardiovascular disease events JF JAMA JO JAMA YR 2013 FD January 2 VO 309 IS 1 SP 27 OP 27 DO 10.1001/jama.2012.116654 UL http://dx.doi.org/10.1001/jama.2012.116654 AB The mean omega-3 PUFA intake of 1.51 g per day (0.77 g/d of eicosapentaenoic acid [EPA] and 0.60 g/d of docosahexaenoic acid [DHA]) of all studies analyzed was approximately half of the 2000 Food and Drug Administration recommendation of 3 g per day of EPA plus DHA to reduce the risk of coronary heart disease.2 Only 5 of the 20 included studies in this analysis tested consumption levels of more than 2 g per day, of which 3 studies had intakes of more than 3 g per day. Thus, it is possible the dietary interventions used in many of the analyzed studies might have been insufficient to provoke the intended cardioprotective outcome that omega-3 consumption or supplementation has been hypothesized to elicit.3