RT Journal A1 Hampton T T1 WHy mole rats are cancer free JF JAMA JO JAMA YR 2013 FD January 2 VO 309 IS 1 SP 20 OP 20 DO 10.1001/jama.2012.173449 UL http://dx.doi.org/10.1001/jama.2012.173449 AB Researchers at the University of Rochester, in New York, and their colleagues found that fibroblast cells from the rats proliferate actively for 7 to 20 population doublings, after which the cells begin secreting interferon-beta, and the cultures undergo massive necrotic cell death within 3 days. This phenomenon depends on the p53 and retinoblastoma tumor suppressor proteins.