RT Journal A1 Friedrich MJ T1 NEw research on alzheimer treatments ventures beyond plaques and tangles JF JAMA JO JAMA YR 2012 FD December 26 VO 308 IS 24 SP 2553 OP 2555 DO 10.1001/jama.2012.93816 UL http://dx.doi.org/10.1001/jama.2012.93816 AB That's not for lack of trying, said Lennart Mucke, MD, PhD, director of the Gladstone Institute of Neurological Disease at the University of California, San Francisco, who spoke at the annual meeting of the Society for Neuroscience. While research is contributing to a better understanding of the disease, these mechanistic insights haven't yet translated into successful therapies, he said.