RT Journal
A1 Yeboah J, Greenland P, Herrington DM
T1 MArkers for prediction of cardiovascular disease risk—reply
JF JAMA
JO JAMA
YR 2012
FD December 26
VO 308
IS 24
SP 2561
OP 2562
DO 10.1001/jama.2012.25796
UL http://dx.doi.org/10.1001/jama.2012.25796
AB 
In Reply: Our study showed the superiority of CAC for improving discrimination for incident CHD and CVD in individuals classified as intermediate risk by the Framingham risk score. We agree with Dr Kavousi and colleagues that contemporary CHD risk prediction models such as the Framingham risk score are not necessarily optimized to also predict CVD, which typically includes cerebrovascular outcomes in the composite definition. This is an important limitation to bear in mind as the scientific and clinical communities seek to broaden the scope of vascular disease outcomes that are targeted by prediction and prevention measures.