RT Journal
A1 Kavousi M, Leening MG, Witteman JM
T1 MArkers for prediction of cardiovascular disease risk
JF JAMA
JO JAMA
YR 2012
FD December 26
VO 308
IS 24
SP 2561
OP 2562
DO 10.1001/jama.2012.25786
UL http://dx.doi.org/10.1001/jama.2012.25786
AB 
To the Editor: The article by Dr Yeboah and colleagues1 compared the ability of several risk markers to improve prediction of coronary heart disease (CHD) and cardiovascular disease (CVD) among individuals at intermediate risk. The authors reported that coronary artery calcium (CAC) provided superior reclassification compared with other risk markers and recommended CAC as a tool for refining cardiovascular risk prediction in individuals at intermediate risk. While the added predictive ability of CAC in CHD risk prediction was substantial and confirmed previous findings,2 we believe that supporting CAC as a candidate for CVD screening based on the results is less grounded.