RT Journal A1 Kuehn BM T1 TAckling autoimmunity JF JAMA JO JAMA YR 2012 FD December 26 VO 308 IS 24 SP 2557 OP 2557 DO 10.1001/jama.2012.156146 UL http://dx.doi.org/10.1001/jama.2012.156146 AB In patients with multiple sclerosis, T cells inappropriately attack the myelin that protects neurons and may result in progressive neurologic symptoms. Currently, many treatments for such disorders work by nonselectively down-regulating immune function. But this can leave patients vulnerable to complications, such as infection, so scientists have been seeking ways to selectively turn down aberrant immune activity.