RT Journal
A1 Arterburn DE, O’Connor PJ
T1 A look ahead at the future of diabetes prevention and treatment
JF JAMA
JO JAMA
YR 2012
FD December 19
VO 308
IS 23
SP 2517
OP 2518
DO 10.1001/jama.2012.144749
UL http://dx.doi.org/10.1001/jama.2012.144749
AB 
In this issue of JAMA, Gregg and colleagues report findings from an exploratory analysis of the Look AHEAD trial demonstrating that intensive lifestyle intervention is superior to conventional diabetes education and treatment for inducing a transient partial remission of type 2 diabetes.3 At 2, 3, and 4 years, respectively, 9.2%, 6.4%, and 3.5% of intensive lifestyle intervention participants (n=2262) had partial diabetes remission compared with 1.7%, 1.3%, and 0.5% of participants in the diabetes support and education group (n=2241). Complete remission was less common: 1.3% and 0.7% at 1 and 4 years. Following partial remission, one-third of lifestyle intervention participants relapsed to diabetes each year. Participants with early-stage diabetes (shortest duration, not treated with insulin, good baseline glycemic control) were most likely to benefit from the intensive lifestyle intervention. Look AHEAD has already shown that intensive lifestyle modification can induce significant improvements in other intermediate health indicators, such as body weight, fitness, blood pressure, glycemic control, and lipids.4