RT Journal
A1 Shmerling RH
T1 Management of gout: A 57-year-old man with a history of podagra, hyperuricemia, and mild renal insufficiency
JF JAMA
JO JAMA
YR 2012
FD November 28
VO 308
IS 20
SP 2133
OP 2141
DO 10.1001/jama.2012.65028
UL http://dx.doi.org/10.1001/jama.2012.65028
AB Gout is an ancient disease. Despite significant advances in the understanding of its risk factors, etiology, pathogenesis, prevention, and treatment, millions of people with gout experience repeated attacks of acute arthritis and other complications. The incidence of gout is increasing, most likely reflecting increasing rates of obesity and other lifestyle factors, including diet. Comorbid conditions that often accompany gout, including chronic kidney disease and diabetes mellitus, present challenges for the management of gout. Using the case of Mr R, a 57-year-old man with a history of podagra, hyperuricemia, and mild renal insufficiency, the diagnosis and treatment of gout are discussed. For those with moderate to severe gout, urate-lowering treatment can eliminate acute attacks of arthritis and prevent complications. In the near future, it is likely that new risk factors for gout will be identified and new ways of preventing and managing this common disease will become available.