RT Journal A1 Moses III H, Dorsey E T1 BIomedical research in an age of austerity JF JAMA JO JAMA YR 2012 FD December 12 VO 308 IS 22 SP 2341 OP 2342 DO 10.1001/jama.2012.14846 UL http://dx.doi.org/10.1001/jama.2012.14846 AB The National Institutes of Health (NIH) budget would be reduced by $2.5 billion, or about 8.2%.1 Given that three-fourths of the NIH budget is committed to previously awarded grants, sequestration could affect predominantly new applications and young researchers. These budget reductions at the NIH and at other research agencies, such as $0.5 billion at the Centers for Disease Control and Prevention and $0.6 billion at the National Science Foundation (Table), will exacerbate tensions between large infrastructure projects (such as those that maintain public databases in genomics, clinical trials, and bioinformatics) and small investigator-initiated grants, which historically have been the primary source of new clinical insights.