RT Journal
A1 Kuehn BM
T1 SCientists confront joint hiv-tb epidemics by taking fight to the front lines
JF JAMA
JO JAMA
YR 2012
FD November 21
VO 308
IS 19
SP 1959
OP 1960
DO 10.1001/jama.2012.14752
UL http://dx.doi.org/10.1001/jama.2012.14752
AB 
The emergence of extensively drug-resistant tuberculosis (XDR-TB) in patients at a rural hospital in the KwaZulu-Natal province of South Africa gained international attention in 2005. By that point, physicians had become accustomed to encountering cases of multidrug-resistant TB (MDR-TB). When first-line antibiotics failed, they knew they could turn to more toxic and less effective second-line choices. But the outbreak in KwaZulu-Natal led to the “recognition that untreatable TB was out there,” explained William R. Bishai, MD, PhD, codirector of the Johns Hopkins Center for Tuberculosis Research in Baltimore.