RT Journal
A1 Rosch EC
T1 INterferon-γ-release assays for latent tuberculosis
JF JAMA
JO JAMA
YR 2012
FD November 21
VO 308
IS 19
SP 1971
OP 1971
DO 10.1001/jama.2012.12817
UL http://dx.doi.org/10.1001/jama.2012.12817
AB 
As the population ages, many persons develop acute and chronic illnesses and may be exposed to immunomodulating therapies. In such situations, a negative PPD test may not ensure the absence of tuberculosis but merely reflect an acquired biological inability to respond to the protein antigen. The addition of anergy panel agents to the skin testing regimen increases the expense and complexity. Also, these agents are not routinely available in most primary care outpatient settings.