RT Journal A1 Beletsky L, Rich JD, Walley AY T1 PRevention of fatal opioid overdose JF JAMA JO JAMA YR 2012 FD November 14 VO 308 IS 18 SP 1863 OP 1864 DO 10.1001/jama.2012.14205 UL http://dx.doi.org/10.1001/jama.2012.14205 AB During the time it typically takes some overdoses to turn fatal, it is possible to reverse the respiratory depression and other effects of opioids with the antagonist naloxone. Community-based organizations, health care institutions, and local and state agencies have begun to train and equip potential nonmedical bystanders to recognize and reverse overdose events using first aid techniques and emergency supplies of naloxone.2- 3 As the number of such initiatives has increased, the 53 000 program trainees have tracked more than 10 000 reports of overdose rescues in the United States.2 These efforts have targeted drug users (syringe access programs, drug treatment centers, correctional facilities),1 physicians (to “co-prescribe” naloxone along with opioids),4 and first responders (ie, fire and police).3 The concept has also gained traction among policy makers, including the Office of the National Drug Control Policy and professional organizations.5