RT Journal
A1 Hampton T
T1 PIgs and pandemic influenza
JF JAMA
JO JAMA
YR 2012
FD November 7
VO 308
IS 17
SP 1729
OP 1729
DO 10.1001/jama.2012.28158
UL http://dx.doi.org/10.1001/jama.2012.28158
AB 
The lethal virus acquired simultaneous mutations in hemagglutinin and neuraminidase proteins during the single ferret passage, leading to greater virulence and transmissibility. The virus also demonstrated enhanced infectivity and growth in mice and human lung tissues. The authors noted that mutations in the 2 proteins that played an important role in the virus' pathogenicity and transmissibility could serve as potential virulence markers in mammals.