RT Journal A1 Bach PB T1 COmputed tomographic screening for lung cancer—reply JF JAMA JO JAMA YR 2012 FD October 3 VO 308 IS 13 SP 1320 OP 1321 DO 10.1001/2012.jama.11898 UL http://dx.doi.org/10.1001/2012.jama.11898 AB While risk prediction is an intriguing area of research, Young and colleagues' approach may overlook important factors in the risk-benefit calculus.1 For instance, while identifying patients at increased risk of cancer is important (ie, these are the individuals who may benefit from screening), there are factors other than risk to consider when determining the magnitude of the expected benefits and risks.