RT Journal
A1 Welte T, Brunkhorst F, Kuhnt E
T1 TReatment of sepsis-related organ dysfunction—reply
JF JAMA
JO JAMA
YR 2012
FD September 26
VO 308
IS 12
SP 1206
OP 1207
DO 10.1001/2012.jama.11271
UL http://dx.doi.org/10.1001/2012.jama.11271
AB 
In Reply:  Both Dr Rodríguez-Baño and Dr Du and colleagues raise similar concerns that the treatment options of meropenem monotherapy vs meropenem plus moxifloxacin used in our study appear to contradict current guidelines for the treatment of severe community-acquired pneumonia, which recommend a combination of a β-lactam and a macrolide or an antipseudomonal β-lactam combined with an aminoglycoside or ciprofloxacin in cases of suspected Pseudomonas infection.1 While we agree with these recommendations for treating pneumonia, our study focused on patients with severe sepsis and septic shock independent of the focus of infection.