RT Journal A1 Friedrich MJ T1 STudies probe mechanisms that have a role in obesity-associated morbidities JF JAMA JO JAMA YR 2012 FD September 19 VO 308 IS 11 SP 1077 OP 1079 DO 10.1001/2012.jama.11024 UL http://dx.doi.org/10.1001/2012.jama.11024 AB Although researchers have yet to discover a unifying pathological mechanism underlying the development of metabolic syndrome, they have learned much about how excess adiposity can perturb normal metabolic functions. In particular, the relationship between obesity and chronic low-grade inflammation in various tissues of the body, such as adipose tissue, has been the subject of intense research.